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March, 04 2019

Cerium oxide nanoparticles could improve the prognosis of hepatocellular carcinoma

Hepatocellular carcinoma is s the most common type of primary liver cancer and is ranked as the third cancer with the highest mortality. Effective treatment is currently unavailable after the early stages of the disease. When it is no longer possible to follow ablation in the first stages of progression, the best therapeutic approaches do not succeed in the progression of the disease. According to the journal Hepatology, this could change thanks to an experimental treatment based on cerium oxide nanoparticles in which the Augusto Pi and Sunyer Biomedical Research Institute (IDIBAPS) has been working for a long time together with the Catalan Institute of Nanoscience and Nanotechnology (ICN2).

This work explains how, thanks to their antioxidant and anti-inflammatory properties, the cerium oxide nanoparticles have been able to partially reverse the cellular mechanisms involved in tumor progression. Moreover, they have managed to significantly increase survival in animal models like rats. The last authors of the study are Professor Wladimiro Jiménez, Head of the Biochemistry Department of the Biomedical Diagnostics Centre of the Hospital Clinic of Barcelona and also Head the IDIBAPS group called Translational research in new therapeutic and diagnostic strategies in liver diseases and Pofessor ICREA Víctor F. Puntas, Head of the ICN2 Group of InorganicNanoparticles and also of the Pharmacokinetic Nanoparticles Group of the Vall de Hebrón Research Institute (VHIR). The first author is Guillermo Fernández-Varo, member of the mentioned above research group IDIBAPS and of the CIBER of Liver and Digestive Diseases (CIBERehd).

The treatment based on cerium oxide nanoparticles, with no side effects, matched the results of the best therapeutic option available today and this could result in an innovative pharmacological strategy for a disease in need of new therapies.

 

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