Clínic Barcelona. Hospital Universitari

Mercè Brunet Serra

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Head of Section

Hospital Clínic – Biomedical Diagnostic CenterBiochemistry and Molecular Genetics

  • Therapeutic drug monitoring of Immunosuppressive Drugs: tacrolimus, cyclosporine, mycophenolic acid, sirolimus, and everolimus by LC/MS/MS or immunoassay.Pharmacogenetics.
  • Antitumor therapeutic drug monitoring in different biological matrix:Imatinib, Temsirolimus, Sorafenib, and Doxorubicine by LC/MS/MS. Pharmacogenetics/personal response.
  • Pharmacogenetics. Analysis of genetic polymorphisms that affect expression and activity of therapeutic targets biotransformation enzymes and transport regulatory proteins.
  • Pharmacodynamic and pharmacogenetic study of biomarkers that reflect the diversity of response to treatment in solid organ and bone marrow transplantation.
  • Studies on the clinical impact of genetic mutations, which affect the target proteins and biotransformation enzymes in the choice of treatment.
  • Pharmacokinetic and pharmacodynamic studies of antitumor drugs. Analysis of the drug in different biological matrix, biomarkers of individual response and clinical outcome.
  • Evaluation of antitumor treatment guidelines established for specific populations, to identify this type of treatment and improve its efficacy and safety profile.
  • Introduction of mass spectrometry in the clinical laboratory diagnosis in the fields of pharmacology and toxicology. International workshop

Other charges

  • Escrigui el seu càrrec (Anglès)

    Hospital Clínic – CDB Centro de Diagnóstico Biomédico – Biochemistry and Molecular Genetics

  • Director of Studies Phase I Pharmacology Laboratory

    Hospital Clínic – CDB Centro de Diagnóstico Biomédico – Biochemistry and Molecular Genetics

  • Director of Education of the Council of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology.

Recent articles

Academic Qualifications

  • (1993)
  • (1990)
  • (1980)

Biomedical Diagnostic Center (CDB)

Villarroel, 170 · 08036 Barcelona
Tel: +34 93 227 54 64 · Fax: +34 93 227 98 75 · · www.hospitalclinic.org